912545-86-9

Product NameSmoothened agonist
Molecular FormulaC28H28ClN3OS
Molecular Weight490.069
Purity99%

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CasNo： 912545-86-9
Molecular Formula： C28H28ClN3OS
Purity： 99%

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What is the Smoothened agonist ?

Smoothened agonist is , while it's Molecular Formula is C28H28ClN3OS. Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:to study its effects on mouse hippocampal cellsto determine its effects on the mitochondrial network in zebrafish embryoto study its effects on murine embryonic fibroblasts

What is the CAS number for Smoothened agonist ?

The CAS number of Smoothened agonist is 912545-86-9.

More information of Smoothened agonist 912545-86-9 are:

Synonyms	3-chloro-N-(4-(methylamino)cyclohexyl)-N-((3-(pyridin-4-yl)phenyl)methyl)-1-benzothiophene-2-carboxamide;SAG1.3;SAG 1.1;SAG compound;Smoothened Agonist (SAG)
CAS Number	912545-86-9
Molecular Formula	C28H28ClN3OS
Molecular Weight	490.069
Density	1.30±0.1 g/cm3(Predicted)
Boiling Point	688.6±55.0 °C(Predicted)
HS CODE	2934999090
PSA	73.47000
LogP	7.18060
Pka	10?+-.0.40(Predicted)

What is Smoothened agonist (912545-86-9) used for?

SAG (912545-86-9) is a smoothened agonist which binds directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 μM (EC50?for SMO activation is ~ 3 nM).1

Articles related to Smoothened agonist:

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Potent agonists of the Hedgehog signaling pathway

Brunton, Shirley A.,Stibbard, John H.A.,Rubin, Lee L.,Guicherit, Oivin M.,Kruse, Lawrence I.,Price, Stephen,di Lucrezia, Raffaella,MacKinnon, Colin H.,Avery, Alaric,Park, Yvonne,Buxton, Danielle,Boyd, Edward A

scheme or table, p. 4308 - 4311 (2010/04/26)

How to get the best price on Smoothened agonist?

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