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2,2-difluoro-2-(fluorosulfonyl)acetate
N-(2-iodo-6-bromo-4-heptafluoroisopropylphenyl)-2-fluoro-3-(N-methylbenzamido)benzamide
![3-[benzoyl(methyl)amino]-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide](/upload/2026/7/c92e698d-8e50-4890-bced-abec63728ed0.png)
3-[benzoyl(methyl)amino]-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide;
In
N,N-dimethyl-formamide;
at 100 ℃;
|
53% |
2-fluoro-3-(N-methylbenzamido)-N-(2-(trifluoromethyl)-4-(heptafluoroisopropyl)phenyl)benzamide
3-[benzoyl(methyl)amino]-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide
| Conditions | Yield |
|---|---|
|
With
sodium chlorate; sodium bromide; sodium hydroxide;
In
dichloromethane; water;
at 40 ℃;
for 2h;
|
99.5% |
|
With
sodium hypochlorite; sodium bromide; sodium hydroxide;
In
dichloromethane; water;
at 40 ℃;
for 1h;
Reagent/catalyst;
Solvent;
Temperature;
|
96% |
|
2-fluoro-3-(N-methylbenzamido)-N-(2-(trifluoromethyl)-4-(heptafluoroisopropyl)phenyl)benzamide;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.166667h;
Cooling with ice;
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 2h;
Concentration;
|
82% |
|
With
sodium chlorate; sodium bromide; sodium hydroxide;
In
water; 1,2-dichloro-ethane;
at 40 ℃;
for 1.5h;
Reagent/catalyst;
Temperature;
Solvent;
|
61.1 g |
N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide
benzoyl chloride
2-(trifluoromethyl)benzenamine
4-(perfluoropropane-2-yl)-2-(trifluoromethyl)aniline
N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-N-methyl-3-(N-methylbenzamide)benzamide
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