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Medetomidine Hydrochloride is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required. The IV route of administration is more efficacious for dental care.
Medetomidine is used in method for synthesizing Medetomidine using 2,3-Dimethylphenylmagnesium Bromide.
1-(1H-imidazol-4-yl)ethan-1-one
medetomidine
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / 2.5 h / 20 - 25 °C / Reflux
1.2: 10 h / 20 °C
2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h / -10 - 20 °C
With
triethylsilane; iodine; magnesium; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
|
5-(1-(2,3-dimethylphenyl)ethyl)-4-tosyl-4,5-dihydrooxazole
medetomidine
| Conditions | Yield |
|---|---|
|
With
ammonia;
In
ethanol;
at 110 ℃;
for 3h;
|
89% |
|
With
ammonia;
at 110 ℃;
for 3h;
|
89% |
The CAS number of Medetomidine is 86347-14-0.
More information of Medetomidine 86347-14-0 are:
|
CAS Number |
86347-14-0 |
|
Density |
1.053 g/cm3 |
|
Melting Point |
151.5 - 152.5oC |
|
Boiling Point |
381.9 °C at 760 mmHg |
|
Flash Point |
191.3 °C |
|
Vapor Pressure |
1.08E-05mmHg at 25°C |
|
Refractive Index |
1.569 |
|
HS CODE |
2933290090 |
|
PSA |
28.68000 |
|
LogP |
3.17830 |
|
Pka |
14.29±0.10(Predicted) |
Synonyms for Medetomidine 86347-14-0:1H-Imidazole,4-[1-(2,3-dimethylphenyl)ethyl]- (9CI);Domtor;Medetomidine;dl-Medetomidine;
The chemical formula of Medetomidine is C13H16N2 which containing 13 Carbon atoms,16 Hydrogen atoms and 2 Nitrogen atoms,and the molecular weight of Medetomidine is 200.283.
Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.
InChI:InChI=1/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
Relevant articles related to Medetomidine:
|
Article |
Source |
|
Novel method for the preparation of Medetomidine |
- , (2021/02/09) |
|
Preparation method of dexmedetomidine hydrochloride |
- Paragraph 0036; 0038-0046, (2020/07/02) |
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