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ACT-132577 is , while it's Molecular Formula is C16H14Br2N6O4S. N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
The CAS number of ACT-132577 is 1103522-45-7.
More information of ACT-132577 1103522-45-7 are:
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Synonyms |
ACT-132577;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;N-Despropyl Macitentan |
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CAS Number |
1103522-45-7 |
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Molecular Formula |
C16H14Br2N6O4S |
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Molecular Weight |
546.199 |
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Density |
1.841±0.06 g/cm3(Predicted) |
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Boiling Point |
705.0±70.0 °C(Predicted) |
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PSA |
150.59000 |
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LogP |
4.38590 |
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Pka |
13.56±0.60(Predicted) |
ACT-132577 is a drug compound that belongs to the family of endothelin receptor antagonists. It is an active metabolite of N-Despropyl-macitentan and is used for the treatment of pulmonary arterial hypertension (PAH). Endothelin receptor antagonists work by blocking the action of endothelin-1, a potent vasoconstrictor, thereby reducing blood vessel constriction and improving blood flow in PAH patients.
Articles related to ACT-132577:
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Article |
Source |
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CRYSTALLINE FORMS OF A 4-PYRIMIDINESULFAMIDE DERIVATIVE APROCITENTAN |
- Paragraph 0231, (2020/01/22) |
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PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES |
- Page/Page column 45, (2015/09/22) |
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