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Histamine receptor, Alzheimer research
cyanocobalamin
trimethyloxosulfonium bromide
CH3Cb1
dimethylsulfide
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate; cobalt(II) chloride;
In
water; butanone;
at 15 - 40 ℃;
|
cyanocobalamin
trimethyloxosulfonium bromide
CH3Cb1
| Conditions | Yield |
|---|---|
|
cyanocobalamin;
With
sodium tetrahydroborate; cobalt(II) chloride;
In
water; butanone;
at 30 - 50 ℃;
for 1.66667 - 2.5h;
trimethyloxosulfonium bromide;
In
water; butanone;
at 15 - 50 ℃;
|
85% |
The CAS number of Mecobalamin is 13422-55-4.
More information of Mecobalamin 13422-55-4 are:
|
CAS Number |
13422-55-4 |
|
Melting Point |
>190°C (dec.) |
|
HS CODE |
29362600 |
|
PSA |
463.87000 |
|
LogP |
7.19930 |
|
Pka |
pK1:7.64(+1) (25°C) |
Synonyms for Mecobalamin 13422-55-4:Cobinamide,Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-esterwith 5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole;Algobaz;Co-Methylcobalamin;Cobalamin, Co-methyl-;Hitocobamin M;MeCbl;Methycobal;Methyl cobalamine;Methyl vitamin B12;Methyl-5,6-dimethylbenzimidazolylcobalamin;Methyl-B12;Methylcob(III)alamin;Methylcobalamine;
The chemical formula of Mecobalamin is C63H91CoN13O14P which containing 63 Carbon atoms,91 Hydrogen atoms,1 Cobalt atoms,13 Nitrogen atoms,14 Oxygen atoms and 1 Phosphorus atoms,and the molecular weight of Mecobalamin is 1344.46.
Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
InChI:InChI=1/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2/t31?,34-,35-,36-,37+,41+,52?,53?,56?,57+,59-,60+,61+,62+;;/m1../s1
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