Your Location：Home >Products >Pharmaceutical intermediates >1075236-89-3
Product Details
The present invention relates to methods...
Tricyclic nitrogen containing compounds ...
![3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde](/upload/2026/7/911b46e0-46b8-405e-8c49-9fa102db5c6f.png)
3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde
![(2R)-2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione](/upload/2026/7/4e054620-43a3-43fd-9043-f0063addf141.png)
(2R)-2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione
gepotidacin
| Conditions | Yield |
|---|---|
|
3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde; (2R)-2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione;
In
methanol; chloroform;
at 20 ℃;
With
sodium tris(acetoxy)borohydride;
In
methanol; chloroform;
at 20 ℃;
for 0.5h;
With
water; sodium hydrogencarbonate;
In
methanol; chloroform;
|
|
|
With
methanol; sodium tris(acetoxy)borohydride;
In
chloroform;
at 20 ℃;
for 0.5h;
Inert atmosphere;
|
![2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol](/upload/2026/7/b4f53dc7-37ad-40de-91d7-35e24fb7e02f.png)
2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol
gepotidacin
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 11 steps
1.1: toluene-4-sulfonic acid / 20 °C
1.2: 0.33 h
2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane / 20 °C / 760.05 Torr
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: sodium hydride / tetrahydrofuran / 3.25 h / 0 - 20 °C
5.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C
6.2: pH ~ 8
7.1: triethylamine / chloroform / 4.5 h / Heating / reflux
8.1: pyridine / acetonitrile / 5 h / 50 - 90 °C
9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C
10.1: isopropylamine / methanol; acetonitrile / Resolution of racemate
11.1: methanol; chloroform / 20 °C
11.2: 0.5 h / 20 °C
With
pyridine; hydrogenchloride; manganese(IV) oxide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; isopropylamine; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
|
|
|
Multi-step reaction with 11 steps
1: toluene-4-sulfonic acid / 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 20 °C / 760.05 Torr
3: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4: sodium hydride / tetrahydrofuran; mineral oil / 1.25 h / 0 - 20 °C / Inert atmosphere
5: manganese(IV) oxide / dichloromethane / 20 °C
6: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C
7: triethylamine / chloroform / 4.5 h / Reflux; Inert atmosphere
8: pyridine / acetonitrile / 50 °C / Reflux
9: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C
10: isopropylamine / methanol; acetonitrile / Resolution of racemate
11: sodium tris(acetoxy)borohydride; methanol / chloroform / 0.5 h / 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; methanol; manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; isopropylamine; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
|
3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde
(2R)-2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione
2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol
2-chloro-6-methoxy-3-nitropyridine
CAS：9003-07-0
CAS：533-67-5
CAS：936015-60-0
CAS：149-32-6
