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Product Details
|
General Description |
N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate. |
InChI:InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
A series of nonguanidine N1-activated C4...
1-(trans-[123I]Iodopropen-2-yl)-4-(4-cya...
A new family of nonquaternary reactivato...
5-Bromo-N-[4-(6,7-dimethoxy-3,4-dihydro-...
A new water-soluble porphyrin, 5,10,15,2...
Employing a bifunctional catalyst based ...
Four distinctive sets of optimum nitroxy...
Catalyst controlled site-selective C-H f...
N-tert-butoxycarbonyl (N-Boc) amines are...
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
| Conditions | Yield |
|---|---|
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 0.833333h;
With
ammonium chloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.75h;
|
97% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
96% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
|
94% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 16h;
|
93% |
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
|
89% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
89% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
89% |
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
With
sodium hydroxide;
In
tetrahydrofuran; water;
|
89% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
89% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
84% |
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 25 ℃;
With
water; sodium hydroxide;
In
tetrahydrofuran;
|
77% |
|
With
15-crown-5; (1-(2-(2,3-diisopropyl-1-methylguanidino)ethyl)-3-mesityl-1,3-dihydro-2H-imidazol-2-ylidene)copper(I) chloride; hydrogen; sodium t-butanolate;
In
1,4-dioxane;
at 60 ℃;
for 24h;
Inert atmosphere;
|
74% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 45 ℃;
for 6h;
|
72.53% |
|
With
diisobutylaluminium hydride;
In
benzene;
at 20 ℃;
for 3h;
|
46% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
|
|
With
sodium hydroxide; lithium aluminium tetrahydride;
In
tetrahydrofuran; water;
|
22.72 g (84%) |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
|
|
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
for 1h;
With
water; rochelle salt;
In
toluene;
|
|
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
With
water; sodium sulfate;
In
tetrahydrofuran;
for 0.5h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
|
|
|
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
|
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
With
sodium hydroxide; water;
In
tetrahydrofuran;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
|
![N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid](/upload/2026/7/9c6a14b1-62de-4c8d-9219-1bc9e5e928e8.png)
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
| Conditions | Yield |
|---|---|
|
With
borane-THF;
In
tetrahydrofuran;
|
100% |
|
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid;
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
methanol;
|
96% |
|
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 0.666667h;
Inert atmosphere;
|
89% |
|
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2.25h;
|
88% |
|
With
borane-THF;
In
tetrahydrofuran;
at 25 ℃;
for 2.33333h;
|
85% |
|
With
borane-THF;
In
tetrahydrofuran;
at 0 - 25 ℃;
|
84% |
|
With
borane-THF;
at 0 - 25 ℃;
|
84% |
|
With
diborane;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Inert atmosphere;
|
80% |
|
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 7h;
|
76% |
|
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Cooling with ice;
|
75% |
|
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
1,2-dimethoxyethane;
at 0 ℃;
With
sodium tetrahydroborate;
|
|
|
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
|
|
|
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 4h;
|
|
|
In
tetrahydrofuran;
|
|
|
In
tetrahydrofuran;
|
|
|
With
borane-THF;
In
tetrahydrofuran;
at -40 - 0 ℃;
for 3h;
Cooling with acetone-dry ice;
|
|
|
With
borane-THF;
In
tetrahydrofuran;
at 20 ℃;
|
|
|
With
sodium tetrahydroborate; boron trifluoride diethyl etherate;
In
tetrahydrofuran;
|
|
|
With
borane;
In
tetrahydrofuran; methanol;
|
|
|
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at -5 - 0 ℃;
for 3.5h;
Time;
|
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate
4-piperidinemethanol
di-tert-butyl dicarbonate
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate
4-(1-t-butoxycarbonylpiperidin-4-ylmethoxy)benzaldehyde
C35H54N8O11S
tert-butyl 4-(bromomethyl)piperidine-1-carboxylate
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