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InChI:InChI=1/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1
A series of C-10 acetal artemisinin dime...
Stoichiometric reduction of artemisinin ...
A one-pot preparation of artemether, art...
Arteether (6) has been prepared from dih...
The natural product artemisinin and deri...
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Artemisinin is a naturally occurring ant...
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Artemisinin or qinghaosu has now largely...
Artemisinins are the most potent and saf...
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Artemisinin (Qinghaosu, 1) is a sesquite...
Cerebral malaria is a serious and someti...
We report herein the synthesis and antic...
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C12H13O2(CH3)3(O)(OO)
dihydroartemisinin
| Conditions | Yield |
|---|---|
|
With
methanol; sodium tetrahydroborate;
at 0 ℃;
for 3h;
|
98% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 3.33333h;
|
97.15% |
|
With
sodium tetrahydroborate;
In
methanol;
for 1.25h;
|
96% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 1.25h;
|
95% |
|
With
lithium triethylborohydride;
In
tetrahydrofuran;
at 2 ℃;
for 0.166667h;
Reagent/catalyst;
Concentration;
Temperature;
Time;
Solvent;
Inert atmosphere;
Flow reactor;
|
94% |
|
With
methanol; sodium tetrahydroborate;
at 0 ℃;
for 2h;
|
94% |
|
With
sodium tetrahydroborate;
|
91% |
|
With
methanol; potassium borohydride; calcium chloride;
Large scale;
|
89% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 1h;
|
89% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 1h;
|
89.57% |
|
With
sodium tetrahydroborate;
|
87% |
|
With
diisobutylaluminium hydride;
In
dichloromethane;
at -78 ℃;
|
87% |
|
With
methanol; sodium tetrahydroborate;
at 0 ℃;
for 3h;
|
86% |
|
With
sodium tetrahydroborate;
at -5 - 0 ℃;
for 2h;
|
85% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 3h;
|
84% |
|
With
sodium tetrahydroborate;
In
methanol;
at -5 - 0 ℃;
for 2h;
|
84% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 1.33333h;
|
84% |
|
With
methanol; sodium tetrahydroborate;
at 0 - 5 ℃;
for 2h;
|
81% |
|
C12H13O2(CH3)3(O)(OO);
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 1h;
With
acetic acid;
In
methanol;
|
78% |
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 2h;
|
75% |
|
With
triethylsilane; zinc(II) iodide;
In
1,2-dichloro-ethane;
at 20 ℃;
for 24h;
|
65% |
|
With
sodium tetrahydroborate;
In
methanol;
for 2h;
Cooling with ice;
|
59% |
|
With
sodium tetrahydroborate;
In
methanol;
|
|
|
With
sodium tetrahydroborate;
In
ethanol;
at 4 ℃;
for 0.666667h;
|
23 mg |
|
With
sodium tetrahydroborate;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 2.91667h;
|
1.6 g |
|
With
sodium tetrahydroborate;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 3h;
|
|
|
With
sodium tetrahydroborate; amberlyst-15;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Further Variations:;
Reagents;
Solvents;
Product distribution;
|
|
|
With
sodium tetrahydroborate;
D-glucose;
In
ethanol;
at 20 - 23 ℃;
for 1h;
|
|
|
With
sodium tetrahydroborate;
D-glucose;
In
ethanol;
at 20 - 23 ℃;
for 0.5h;
|
|
|
With
sodium tetrahydroborate;
D-glucose;
In
ethanol;
at 20 - 23 ℃;
for 1.25h;
|
|
|
With
sodium tetrahydroborate;
D-glucose;
In
ethanol;
at 20 - 23 ℃;
for 1.5h;
|
|
|
With
sodium tetrahydroborate;
3,5-dihydroxyphenol;
In
ethanol;
at 20 - 23 ℃;
for 2h;
|
|
|
With
sodium tetrahydroborate;
D-Galactose;
In
ethanol;
at 20 - 23 ℃;
for 1.5h;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at -5 ℃;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 3.3h;
|
|
|
With
diisobutylaluminium hydride;
In
dichloromethane;
at -78 ℃;
Inert atmosphere;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
Inert atmosphere;
Flow reactor;
|
|
|
With
sodium tetrahydroborate; ethanol; lithium carbonate; lithium chloride;
Reagent/catalyst;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
|
|
|
With
sodium tetrahydroborate;
In
methanol;
at 0 - 5 ℃;
for 5h;
|
|
|
With
methanol; sodium tetrahydroborate;
|
10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin
dihydroartemisinin
![(R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde](/upload/2026/7/4ee265c5-66eb-4589-95a0-61882e18cf5c.png)
(R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde
(3aS,4R,7S,7aR)-4-Methyl-7-((R)-1-methyl-2-oxo-ethyl)-hexahydro-benzofuran-7a-carbaldehyde
| Conditions | Yield |
|---|---|
|
With
hemin; L-Cysteine;
In
water; acetonitrile;
at 23 ℃;
for 24h;
pH=7.4;
Further Variations:;
Reagents;
Product distribution;
|
6 % Spectr. 6 % Spectr. 4 % Spectr. |
C12H13O2(CH3)3(O)(OO)
artemotil
10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin
dihydroartemisinic acid
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