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RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
RU 58841, is a specific androgen receptor antagonist or anti-androgen, that has shown to have effect on hair growth.
The CAS number of RU 58841 is 154992-24-2.
More information of RU 58841 154992-24-2 are:
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CAS Number |
154992-24-2 |
|
Density |
1.397 g/cm3 |
|
Boiling Point |
493.588 °C at 760 mmHg |
|
Flash Point |
252.313 °C |
|
Vapor Pressure |
1.47E-10mmHg at 25°C |
|
Refractive Index |
1.559 |
|
HS CODE |
2933990090 |
|
PSA |
84.64000 |
|
LogP |
2.89968 |
|
Pka |
15.09±0.10(Predicted) |
The chemical formula of RU 58841 is C17H18F3N3O3 which containing 17 Carbon atoms,18 Hydrogen atoms,3 Fluorine atoms,3 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight, and the molecular weight of RU 58841 is 369.343
RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
InChI:InChI=1/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
Relevant articles related to RU 58841:
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Article |
Source |
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Alternative synthesis of the anti-baldness compound RU58841 |
Leonard, Matthew J.,Lingham, Anthony R.,Niere, Julie O.,Jackson, Neale R. C.,McKay, Peter G.,Huegel, Helmut M. , p. 14143 - 14148 (2014/04/17) |
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