What is the Propylphosphonic anhydride?

Propylphosphonic anhydride is Clear light yellow solution, while it's Molecular Formula is C9H21O6P3. Clear light yellow solution Propylphosphonic anhydride may be used in the following studies:As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.Microwave-assissted Fischer indolization of arylhydrazines.As acid activating agent for the direct synthesis of acid azides from carboxylic acids.One-pot synthesis of coumarins.Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.

What is the CAS number for Propylphosphonic anhydride?

The CAS number of Propylphosphonic anhydride is 68957-94-8.

What is Propylphosphonic anhydride (68957-94-8) used for?

Propylphosphonic anhydride is an organic compound that serves as a versatile reagent and promoter in various chemical reactions and synthesis processes.InChI:InChI=1/C9H21O6P3/c1-4-7-16(10)13-17(11,8-5-2)15-18(12,14-16)9-6-3/h4-9H2,1-3H3

What is the Propylphosphonic anhydride?

Propylphosphonic anhydride is Clear light yellow solution, while it's Molecular Formula is C9H21O6P3. Clear light yellow solution Propylphosphonic anhydride may be used in the following studies:As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.Microwave-assissted Fischer indolization of arylhydrazines.As acid activating agent for the direct synthesis of acid azides from carboxylic acids.One-pot synthesis of coumarins.Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.

What is the CAS number for Propylphosphonic anhydride?

The CAS number of Propylphosphonic anhydride is 68957-94-8.

What is Propylphosphonic anhydride (68957-94-8) used for?

Propylphosphonic anhydride is an organic compound that serves as a versatile reagent and promoter in various chemical reactions and synthesis processes.InChI:InChI=1/C9H21O6P3/c1-4-7-16(10)13-17(11,8-5-2)15-18(12,14-16)9-6-3/h4-9H2,1-3H3

68957-94-8

Product NamePropylphosphonic anhydride
Molecular FormulaC₉H₂₁O₆P₃
Molecular Weight318.183
Purity99%
AppearanceClear light yellow solution

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Product Details

Quick Details

CasNo： 68957-94-8
Molecular Formula： C₉H₂₁O₆P₃
Appearance： Clear light yellow solution
Purity： 99%

Factory Sells Best Quality Propylphosphonic anhydride 68957-94-8 with steady supply

Molecular Formula:C9H21O6P3
Molecular Weight:318.183
Appearance/Colour:Clear light yellow solution
Vapor Pressure:7.51E-05mmHg at 25°C
Refractive Index:n20/D 1.418
Boiling Point:353.012 °C at 760 mmHg
Flash Point:180.976 °C
PSA：108.33000
Density:1.247 g/cm³
LogP:4.85910

Propylphosphonic anhydride(Cas 68957-94-8) Usage

Reaction	TP3 is an exceptional reagent for amide/peptide bond formation. The product is very easy to use and combines excellent?reaction selectivity, low epimerization, high yields and high product purities. Conversions of acids and amides to nitriles under mild conditions. Synthesis of urea and carbamate derivatives. Formation of thioacids from N-protected amino acids and peptides.
Flammability and Explosibility	Notclassified
General Description	Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.

InChI:InChI=1/C9H21O6P3/c1-4-7-16(10)13-17(11,8-5-2)15-18(12,14-16)9-6-3/h4-9H2,1-3H3

68957-94-8 Relevant articles

Synthesis method of 1-propyl phosphoric acid cyclic anhydride

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Paragraph 0055; 0059-0063; 0067-0071; 0075-0079; 0083-0086, (2020/09/16)

The invention provides a 1-propyl phosph...

Preparation method of cyclic propyl phosphonic anhydride

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Paragraph 0046; 0047; 0048; 0055; 0056; 0057, (2017/09/01)

The invention belongs to the technical f...

An improved 1-propyl phosphonic acid of anhydrides and nitriles preparation method (by machine translation)

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Paragraph 0024; 0025, (2016/10/07)

The invention relates to an improved pre...

An optimized and scalable synthesis of propylphosphonic anhydride for general use

Pizova, Hana,Bobal, Pavel

, p. 2014 - 2017 (2015/03/30)

Abstract Propylphosphonic anhydride (T3P...

68957-94-8 Process route

: 18755-43-6
propanephosphonic acid dimethyl ester

: 68957-94-8
2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide

Conditions

Conditions	Yield
With acetic anhydride; 1-ethyl-3-methylimidazolium tetrafluoroborate; at 45 ℃; for 4.5h; Temperature; Reflux;	95.14%

: 4708-04-7
propylphosphonic dichloride

: 71760-04-8
propylphosphonic anhydride

: 68957-94-8
2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide

Conditions

Conditions	Yield
In toluene; at 90 ℃; for 8h; Concentration; Temperature; Inert atmosphere;	82.93%

68957-94-8 Upstream products

4708-04-7
propylphosphonic dichloride
4672-38-2
propylphosphonic acid
18755-43-6
propanephosphonic acid dimethyl ester
71760-04-8
propylphosphonic anhydride

68957-94-8 Downstream products

486434-84-8
N-[4-([1,2,3]-thiadiazol-4-yl)-phenylmethyl]-4-(4'-trifluoro-methylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide
486434-76-8
N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazol-2-carboxylic acid amide
486434-91-7
N-[3-(4-Trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide
486434-89-3
N-(4'-hydroxybiphenyl-4-yl)methyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide