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Product Details
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Safety Profile |
Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. |
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Purification Methods |
Crystallise 6-methyluracil from EtOH or acetic acid. [Beilstein 24 III/IV 1281.] |
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General Description |
6-Methyluracil is a pyrimidine derivative that serves as a key scaffold in the synthesis of biologically active compounds, particularly in medicinal chemistry. Its derivatives, such as 1-substituted-6-methyluracils, are explored for their therapeutic potential, including antineoplastic, antihypertensive, anti-inflammatory, antiviral, and reverse transcriptase inhibitory properties. 6-Methyluracil's versatility allows for structural modifications, enabling the development of novel pharmacophores with diverse biological activities. |
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Definition |
ChEBI: A pyrimidone that is uracil with a methyl group at position 6. |
InChI:InChI=1/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)
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A series of new triazole-sulfonamide bea...
Prototropic tautomerism was used as a to...
The invention provides a production meth...
Twenty five uridine analogues have been ...
hydrogenchloride
benzaldehyde-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylhydrazone)
6-Methyluracil
benzaldehyde
hydrazine
| Conditions | Yield |
|---|---|
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N-butylamine
6-methyl-2,4-pyrimidine-diyl dibenzoate
6-Methyluracil
N-butylbenzamide
| Conditions | Yield |
|---|---|
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triethylamine;
In
dichloromethane;
for 0.25h;
Heating;
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64% |
pyridine
5-bromo-6-methyl-dihydro-pyrimidine-2,4-dione
4-methyleneoxetan-2-one
urea
1,3,6-trimethyluracil
5-hydroxymethyl-6-methyluracil
5-(4-methoxy-phenylazo)-6-methyl-1H-pyrimidine-2,4-dione
5-(chloromethyl)-6-methyluracil
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