626-48-2

  • Product Name6-Methyluracil
  • Molecular FormulaC5H6N2O2
  • Molecular Weight126.115
  • Purity99%
  • Appearancewhite to off-white crystalline solid
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Product Details

Quick Details

  • CasNo: 626-48-2
  • Molecular Formula: C5H6N2O2
  • Appearance: white to off-white crystalline solid
  • Purity: 99%

6-Methyluracil Good Supplier In Bulk Supply High Purity 626-48-2

  • Molecular Formula:C5H6N2O2
  • Molecular Weight:126.115
  • Appearance/Colour:white to off-white crystalline solid 
  • Vapor Pressure:1.16E-07mmHg at 25°C 
  • Melting Point:318 °C (dec.)(lit.) 
  • Refractive Index:1.489 
  • Boiling Point:420.4 °C at 760 mmHg 
  • PKA:pK1:9.52 (25°C) 
  • Flash Point:208 °C 
  • PSA:65.72000 
  • Density:1.226 g/cm3 
  • LogP:-0.62840 

6-Methyluracil(Cas 626-48-2) Usage

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise 6-methyluracil from EtOH or acetic acid. [Beilstein 24 III/IV 1281.]

General Description

6-Methyluracil is a pyrimidine derivative that serves as a key scaffold in the synthesis of biologically active compounds, particularly in medicinal chemistry. Its derivatives, such as 1-substituted-6-methyluracils, are explored for their therapeutic potential, including antineoplastic, antihypertensive, anti-inflammatory, antiviral, and reverse transcriptase inhibitory properties. 6-Methyluracil's versatility allows for structural modifications, enabling the development of novel pharmacophores with diverse biological activities.

Definition

ChEBI: A pyrimidone that is uracil with a methyl group at position 6.

InChI:InChI=1/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)

626-48-2 Relevant articles

SYNTHESIS AND STUDY OF THE RADIOPROTECTIVE PROPERTIES OF THE PYRIMIDINE ANALOGS OF ISOTHIOURONIUM

Golomolzin, B. V.,Tarakhtii, E. A.,Tregubenko, I. P.,Perova, N. M.

, p. 621 - 623 (1984)

-

-

Donleavy,Kise

, (1943)

-

Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies

Hoda, Nasimul,Manzoor, Shoaib,Petreni, Andrea,Raza, Md Kausar,Supuran, Claudiu T.

supporting information, (2021/07/16)

A series of new triazole-sulfonamide bea...

Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium

Tomanová, Monika,Jedinák, Luká?,Canka?, Petr

supporting information, p. 2621 - 2628 (2019/06/03)

Prototropic tautomerism was used as a to...

Production method of dipyridamole bulk drug

-

Paragraph 0005; 0017, (2018/06/04)

The invention provides a production meth...

Substrate specificity of E. coli uridine phosphorylase. Further evidences of high-syn conformation of the substrate in uridine phosphorolysis

Alexeev,Sivets,Safonova,Mikhailov

, p. 107 - 121 (2017/02/05)

Twenty five uridine analogues have been ...

626-48-2 Process route

hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

benzaldehyde-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylhydrazone)
58010-88-1

benzaldehyde-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylhydrazone)

6-Methyluracil
626-48-2

6-Methyluracil

benzaldehyde
100-52-7

benzaldehyde

hydrazine
302-01-2,78206-91-4,119775-10-9,75013-58-0

hydrazine

Conditions
Conditions Yield
N-butylamine
109-73-9,85404-21-3

N-butylamine

6-methyl-2,4-pyrimidine-diyl dibenzoate
155632-06-7

6-methyl-2,4-pyrimidine-diyl dibenzoate

6-Methyluracil
626-48-2

6-Methyluracil

N-butylbenzamide
2782-40-3

N-butylbenzamide

Conditions
Conditions Yield
triethylamine; In dichloromethane; for 0.25h; Heating;
64%

626-48-2 Upstream products

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626-48-2 Downstream products

  • 13509-52-9
    13509-52-9

    1,3,6-trimethyluracil

  • 147-61-5
    147-61-5

    5-hydroxymethyl-6-methyluracil

  • 100518-02-3
    100518-02-3

    5-(4-methoxy-phenylazo)-6-methyl-1H-pyrimidine-2,4-dione

  • 66947-91-9
    66947-91-9

    5-(chloromethyl)-6-methyluracil

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