What is the Dimethyl fumarate?

Dimethyl fumarate is fine white crystalline powder, while it's Molecular Formula is C6H8O4. fine white crystalline powder Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing

What is the CAS number for Dimethyl fumarate?

The CAS number of Dimethyl fumarate is 624-49-7.

What is Dimethyl fumarate (624-49-7) used for?

In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.

What is the Dimethyl fumarate?

Dimethyl fumarate is fine white crystalline powder, while it's Molecular Formula is C6H8O4. fine white crystalline powder Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing

What is the CAS number for Dimethyl fumarate?

The CAS number of Dimethyl fumarate is 624-49-7.

What is Dimethyl fumarate (624-49-7) used for?

In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.

624-49-7

Product NameDimethyl fumarate624-49-7
Molecular FormulaC₆H₈O₄
Molecular Weight144.127
Purity99%
Appearancefine white crystalline powder

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Product Details

Quick Details

CasNo： 624-49-7
Molecular Formula： C₆H₈O₄
Appearance： fine white crystalline powder
Purity： 99%

Manufacturer supply high quality Dimethyl fumarate624-49-7 624-49-7 with GMP standards

Molecular Formula:C6H8O4
Molecular Weight:144.127
Appearance/Colour:fine white crystalline powder
Vapor Pressure:0.475mmHg at 25°C
Melting Point:102-106 °C(lit.)
Refractive Index:1.435
Boiling Point:193 °C at 760 mmHg
Flash Point:91.1 °C
PSA：52.60000
Density:1.124 g/cm³
LogP:-0.11140

624-49-7 Relevant articles

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Andersen, Jacob Lauwring,Nielsen, Christine Juul F?lled,Gotfred-Rasmussen, Helle,Nissen, Poul,Gesser, Borbala,Rasmussen, Mads Kirchheiner,Iversen, Lars,Funder, Erik Daa,Gothelf, Kurt Vesterager,Toth, Rachel,Arthur, J. Simon C.

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Dimethyl fumarate (DMF)?has been applied...

REACTIONS OF BENZYLCHLOROBIS(TRIPHENYLPHOSPHINE)PALLADIUM(II) WITH DIMETHYL ACETYLENEDICARBOXYLATE

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Protic, imidazolium ionic liquids as media for (Z)- to (E)-alkene isomerization

Janus, Ewa,Lozynski, Marek,Pernak, Juliusz

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The quantitative isomerization of (Z)- t...

Aminal-catalyzed isomerization of and addition to dimethyl maleate

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The amine moiety of aminals adds to dime...

Unusual formation of tetrahydropyridazine-3,4,5,6-tetracarboxylic and pyrroletetracarboxylic esters upon decomposition of methyl diazoacetate in the presence of pyridine

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, p. 187 - 191 (2003)

Thermal, photolytic, and thermocatalytic...

Generation and cycloaddition of polymer-supported azomethine ylide via a 1,2-silatropic shift of α-silylimines: Traceless synthesis of pyrrolidine derivatives

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A donor-acceptor complex enables the synthesis of: E -olefins from alcohols, amines and carboxylic acids

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Small-Molecule Investigation of Diels-Alder Complexes for Thermoreversible Crosslinking in Polymeric Applications

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Zwitterion-Catalyzed Isomerization of Maleic to Fumaric Acid Diesters

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Fumaric acid diesters are important buil...

Dimethyl Fumarate: Heterogeneous Catalysis for the Development of an Innovative Flow Synthesis

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The present work describes the developme...

624-49-7 Process route

: 23652-59-7
4-(pyrrolidin-1-yl)pent-3-en-2-one

: 6832-16-2
methyl diazoacetate

: 85392-47-8
methyl 2-acetyl-4-oxovalerate

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 624-49-7
dimethylfumarate

Conditions

Conditions	Yield
copper(I) triflate; In dichloromethane; at 20 ℃; for 24h;	84%

: 23652-59-7
4-(pyrrolidin-1-yl)pent-3-en-2-one

: 6832-16-2
methyl diazoacetate

: 85392-47-8
methyl 2-acetyl-4-oxovalerate

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 624-49-7
dimethylfumarate

: 4-Oxo-2-[1-pyrrolidin-1-yl-eth-(E)-ylidene]-pentanoic acid methyl ester