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The reaction of nicotine with methyllith...
methylmagnesium bromide
nicotine nitrogen oxide
(S)-6-Methylnicotine
(S)-2-methylnicotine
(S)-6-Methylnicotine
2-methylnicotine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
tetrahydrofuran;
Heating;
1.) 50 deg C, 30 min, 2.) reflux, 2.5 h;
|
methyllithium
nicotin
(S)-6-Methylnicotine
(S)-2-methylnicotine
3-((2S)-1-methylpyrrolidin-2-yl)-4-methylpyridine
2,4-Dimethyl-5-((S)-1-methyl-pyrrolidin-2-yl)-pyridine
(S)-6-Methylnicotine
2-methylnicotine
| Conditions | Yield |
|---|---|
|
In
toluene;
Product distribution;
Mechanism;
Heating;
var conc., var. solv.;
|
methyllithium
nicotin
methylmagnesium bromide
nicotine nitrogen oxide
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