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Quality products make an important contribution to long-term revenue and profitability. Manufacturer supply top purity Mirogabalin besylate 1138245-21-2 with ISO standards
Used in Pharmaceutical Industry:
Mirogabalin besylate is used as a therapeutic agent for the treatment of nerve pain.
It is particularly effective in managing pain caused by diabetic peripheral neuropathy and postherpetic neuralgia due to its mechanism of action that involves binding to calcium channels in the central nervous system, thus reducing the release of neurotransmitters responsible for pain signal transmission.
Common side effects associated with the use of mirogabalin besylate may include dizziness, drowsiness, and headache. It is crucial for patients to adhere to the dosing instructions provided by healthcare professionals and to promptly report any severe or persistent side effects to ensure safe and effective treatment.
DS-5565
benzenesulfonic acid
![[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate](/upload/2026/7/d98d0536-e3b3-474a-9ad3-d43de28716e9.png)
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate
| Conditions | Yield |
|---|---|
|
In
water;
Heating;
|
77% |
|
In
tert-butyl methyl ether; water; acetone;
at -10 - 20 ℃;
for 4.5h;
Reagent/catalyst;
Solvent;
Temperature;
Time;
|
![diethyl [(1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-ylidene]propanedioate](/upload/2026/7/beeb934d-c38a-414c-b5ca-186cd8a12ed5.png)
diethyl [(1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-ylidene]propanedioate
[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1.1: ethanol / 4 h / 20 °C
2.1: potassium hydroxide / ethanol; water / 10 h / 20 °C / Reflux
2.2: 10 - 20 °C
3.1: hydrogenchloride / water; tert-butyl methyl ether / 20 °C
3.3: sponge cobalt; dimethylpolysiloxane / 7.5 h / 40 °C / 3375.34 Torr
4.1: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
hydrogenchloride; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone;
|
|
|
Multi-step reaction with 4 steps
1.1: ethanol / 4 h / 20 °C
2.1: potassium hydroxide / ethanol / 7.5 h / Reflux
2.2: 2 h / 20 °C
2.3: 20 °C
3.1: hydrogenchloride / water; toluene
3.2: sponge nickel / 3 h / 20 °C / 3040.2 Torr
3.3: 0.5 h
4.1: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
hydrogenchloride; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone; toluene;
|
|
|
Multi-step reaction with 4 steps
1: ethanol / 4 h / 20 °C
2: potassium hydroxide / ethanol; water / 8 h / 26 - 27 °C / Reflux
3: ammonium hydroxide; hydrogen; potassium hydroxide / water / 15 h / 40 °C / 3000.3 Torr
4: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
ammonium hydroxide; hydrogen; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone;
|
|
|
Multi-step reaction with 5 steps
1.1: ethanol / 4 h / 20 °C
2.1: potassium hydroxide / ethanol; water / 8 h / 26 - 27 °C / Reflux
3.1: hydrogenchloride / toluene / 22 - 46 °C
4.1: hydrogenchloride / water; tert-butyl methyl ether / 20 °C
4.3: sponge cobalt; dimethylpolysiloxane / 7.5 h / 40 °C / 3375.34 Torr
5.1: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
hydrogenchloride; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone; toluene;
|
|
|
Multi-step reaction with 5 steps
1.1: ethanol / 4 h / 20 °C
2.1: potassium hydroxide / ethanol / 8 h / Reflux
2.2: 20 h / 20 °C
2.3: 20 °C
3.1: hydrogenchloride / water; toluene
4.1: ammonium hydroxide; hydrogen; potassium hydroxide / water / 15 h / 40 °C / 3000.3 Torr
5.1: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
hydrogenchloride; ammonium hydroxide; hydrogen; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone; toluene;
|
|
|
Multi-step reaction with 6 steps
1.1: ethanol / 4 h / 20 °C
2.1: potassium hydroxide / ethanol / 8 h / Reflux
2.2: 20 h / 20 °C
2.3: 20 °C
3.1: hydrogenchloride / water; toluene
4.1: hydrogenchloride / toluene / 22 - 46 °C
5.1: hydrogenchloride / water; tert-butyl methyl ether / 20 °C
5.3: sponge cobalt; dimethylpolysiloxane / 7.5 h / 40 °C / 3375.34 Torr
6.1: acetone; water; tert-butyl methyl ether / 4.5 h / -10 - 20 °C
With
hydrogenchloride; potassium hydroxide;
In
ethanol; tert-butyl methyl ether; water; acetone; toluene;
|
The CAS number of Mirogabalin besylate is 1138245-21-2.
More information of Mirogabalin besylate 1138245-21-2 are:
|
CAS Number |
1138245-21-2 |
Synonyms for Mirogabalin besylate 1138245-21-2:[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate
The chemical formula of Mirogabalin besylate is C6H6O3S*C12H19NO2 which containing 18 Carbon atoms,25 Hydrogen atoms,5 Oxygen atoms and 1 Nitrogen atoms,and the molecular weight of Mirogabalin besylate is 367.466.
Mirogabalin besylate is a prescription medication classified as an alpha-2-delta ligand, primarily utilized for the management of nerve pain associated with conditions such as diabetic peripheral neuropathy and postherpetic neuralgia. It functions by binding to calcium channels in the central nervous system, thereby diminishing the release of neurotransmitters that transmit pain signals, leading to effective pain relief and enhanced functionality for affected individuals.
Relevant articles related to Mirogabalin besylate:
|
Article |
Source |
|
BICYCLIC -AMINO ACID DERIVATIVE |
- Page/Page column 52, (2010/06/17) |
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